The Universal MRT
Dosimetry Solution

Validated, versatile and stand-alone dosimetry software suite
for clinical practice as well as research in molecular radiotherapy.

Experience QDOSE® at Upcoming Events

Meet our team for a live demo, discuss dosimetry with our experts and sign up for your free trial version.

NukMed2020 – Jahrestagung der DGN
Leipzig, Germany | April 22-25

SNMMI 2020: Annual Meeting
New Orleans, USA | June 13-16

Safety and  Efficacy Dosimetry

QDOSE® integrates all dosimetry steps from image data import and processing to analysis and reporting. QDOSE® features comprehensive range of workflows, running in parallel, including planar (2D)-, hybrid (2.5D)- and volumetric (3D) dosimetry as well as a dedicated SIRT dosimetry module in one package.

All Steps in a Single Software

  • 2D and 3D coregistration
  • ROI/VOI drawing and segmentation
  • Curve fitting for time activity curves (TACs)
  • Calculation of cumulated activity
  • Dose calculation
  • Comparison of estimates for different workflows

Designed and Developed by Practitioners

We have been designing innovative solutions helping to establish Molecular Radiotherapy as a widely used oncological treatment modality since 2002. The development of QDOSE® is based on this experience in clinical MRT studies and collaborations with nuclear medicine institutions worldwide.

Why QDOSE®

Stand-alone and lightweight

QDOSE® can be installed on most regular Windows®, is vendor independent and can handle DICOM images from most imaging modalities.

Fully integrated workflow

From image data import to image coregistration, segmentation, dose analysis and reporting – all dosimetry steps in one seamless software.

Validated methodology

Dose calculations according to the MIRD pamphlet No. 16, IDAC-Dose calculation software (ICRP 110) and the ICRP Specific absorbed fractions (ICRP 133).

Easy to use

Guided step-by-step process with continuous consistency check for rapid calculations as well as flexible workflow for more demanding analysis.

Turnkey dosimetry solution

QDOSE® incorporates all necessary components required to perform MRT- and SIRT dosimetry in one package.

Certified medical device

Designed and manufactured in accordance with the European Medical Device Directive (MDD).

Medical Physicist Felix Teske* says: “When I use QDOSE, I can interrupt and save the status of my ongoing dose calculation and come back to it later without losing my reorientation- or VOI-data. I can also reload, change and edit or continue my previous work, e.g. redraw an organ-VOIs without the need to repeat any of the previous steps of my work as more data of further imaging time-points come in during the course of the therapy.

Medical Physics Expert Ulrike Bechler* adds: Moreover, I can actively involve my expertise in the fitting of the time-activity data to optimally reflect the kinetic behavior of the therapeutic agent and, thus, make the calculation of the absorbed dose in organs at risk and in the target regions/lesions more certain, realistic and personalized for the patient”

*Dept. of Nuclear Medicine, University Hospital Leipzig, Director and Chairman: Univ.-Prof. Dr. med. Osama Sabri

CORE FEATURES

Data Import

Importing data is easy in QDOSE®, folders can easily be scanned for images that are sorted automatically.

  • DICOM import of NM/PET/CT and MRI
  • Recursive folder support with energy and head consistency checks
  • Retrospective image adding possibility
  • Specification of image units and calibration factors
  • Easy overview and editing of metadata

Multiple Parallel Workflow

In QDOSE®, users can decide to perform either of the workflows supported, single or in parallel, depending on the data available and loaded.

PRRT treatment methods
  • Planar (2D): Multiple time points of conjugate view imaging
  • Hybrid (2.5D): Multiple time points of conjugate view imaging and one quantitative SPECT/CT imaging time point for improved quantification
  • Volumetric (3D): Multiple time points of quantitative SPECT/CT or PET/CT imaging
SIRT treatments
  • Pre-treatment dosimetry: calculation of lung shunt fraction and dose calculation using 99mTc-MAA scan (planar and SPECT)
  • Post-treatment dosimetry using a single time point of 90Y PET/CT or Bremsstrahlung SPECT/CT

Rigid and Deformable Image Coregistration

Disregard of dosimetry method used (2D, 2.5D or 3D), QDOSE® provides a coregistration method to minimize image- and organ displacements.

  • Automatic- and manual rigid 2D coregistration on whole body and organ level
  • Dedicated 2D coregistration of reference (e.g. vial)
  • Automatic (rigid and deformable) and manual rigid 3D coregistration between time points based on CT
  • Automatic and manual rigid 3D coregistration between SPECT/PET and CT/MRI for the same time point

Advanced Drawing and Segmentation Tools

QDOSE® provides multiple options for ROI- and VOI boundary drawing on planars, SPECT, CT or fused data including

  • Drawing (freehand, polygon, ellipse) and editing of regions in 2D- and 3D
  • Copy/paste of boundaries and segmented ROIs/VOIs between time points
  • Separated handling of volume- and activity regions in 3D
  • Automatic 3D-liver segmentation (AIT-Liverator)
  • Automatic/semi-automatic ROI/VOI segmentation
  • Signal-to-background ratio VOI segmentation
  • Fuzzy logic cluster segmentation

Powerful Curve Fitting Package

The comprehensive and flexible curve fitting package provided in QDOSE® provides the user with a wide range of functionality.

  • Mono-, bi-, or tri-exponential fit to Time Activity Curves (TAC)
  • Calculation of cumulated activity (Ã) featuring multiple options for different TAC segments
  • SPECT calibration factor for hybrid methodology
  • Handling of remainder / total body
  • Exclusion of data points (outliers)
  • Import functionality for additional organs: TACs or cumulated activity (Ã) (e.g. red marrow based on blood sampling data)

Efficacy and Safety Dosimetry

In QDOSE®, users may choose to perform both efficacy and safety dosimetry at the same time.

  • Voxel S kernels enable calculation of dose values and cumulated dose volume histograms (DVHs)
  • Spherical model as continuous interpolation model using power functions
  • Activity extrapolation and nuclide replacement for dose prediction
  • IDAC-Dose 2.1 for phantom based calculations
  • Export of residence times to OLINDA/EXM

REQUEST A DEMO

Request a demo and let us show you how easy it is to start using QDOSE®. Upon request, we can also provide you, without any commitment, with a fully functional license along a full hour training with our dosimetry experts.

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CONTACT

For any queries regarding licensing and pricing please contact the sales representative in your area. Further training and support is provided by ABX-CRO.

Support & Development

ABX-CRO advanced pharmaceutical
services Forschungsgesellschaft

Blasewitzer Straße 78-80
01307 Dresden, Germany

Phone +49 (0) 351 21444-212
Telefax +49 (0) 351 214 44-15

moc.o1586470862rc-xb1586470862a@eso1586470862dq1586470862
www.abx-cro.com

Sales Europe

Dr. Joachim Bender
QDOSE® EU Representative

moc.o1586470862rc-xb1586470862a@eso1586470862dq1586470862
Phone +49 (0) 351 21444-211

ABX-CRO’s quality management is certified according to ISO 9001:2015 as well as ISO 13485:2016.
QDOSE® conforms to the European Medical Device Directive 93/42/EEC and is CE marked as
Medical Product (Class IIa) for clinical use inside the European Union.
Outside the EU, QDOSE® can be used for research purposes only.